产品货号：
Z37374
中文名称：
Glutamate receptor 2/GRIA2抗体
英文名称：
Anti-Glutamate receptor 2/GRIA2 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Glutamate receptor 2/GRIA2 Antibody |
| 指标别名 | GluA2;GluR 2;GluR B;GluR K2;GLUR2;GLURB;Glutamate receptor 2;GRIA2;HBGR2 |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,ICC/IF,IP |
| 基因名称 | GRIA2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human GluR2 Ionotropic glutamate receptor.L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.Binding of the excitatory neurotransmitter L-glutamate induces a conformation change,leading to the opening of the cation channel,and thereby converts the chemical signal to an electrical impulse.The receptor then desensitizes rapidly and enters a transient inactive state,characterized by the presence of bound agonist. |
| 实际分子量 | 99KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Glutamate receptor 2,also known as GLUR2,is a protein that in humans is encoded by the GRIA2 gene.This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA),and function as ligand-activated cation channels.GLUR2's cytogenetic location is 4q32.1.The crystal structures of the GLUR2 ligand-binding core in the apo state and in the presence of the antagonist DNQX,the partial agonist kainate,and the full agonists AMPA and glutamate.GLUR2 plays a major role in depression at synapses in which glutamate remains in the synaptic cleft for prolonged periods of time during normal operation of the synapse.The overexpression of GLUR2 increases dendritic spine size and density in hippocampal neurons,and more remarkably,induces spine formation in GABA-releasing interneurons that normally lack spines. |
| Uniprot ID | P42262 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunocytochemistry/Immunofluorescence(ICC/IF) 1:20～100 Immunocoprecipitation 1:20 |
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